Background and Aim: The rates of disability that accompany medically unexplained symptoms appear to be generally comparable to or greater than those seen with many chronic medical conditions. Methods: The following databases from 2000 to 2019 have been searched such as: Cochrane Collaboration, MEDLINE, CINAHL, EMBASE, Science Direct, ASSIA, Web of Science, Scopus, PubMed and JSTOR. Only cohort, casecontrol and randomized controlled trials studies with full text in English were eligible. Results: Of 214 articles, and after exclusion criteria; 3 articles only were met the inclusion criteria which have the association between disability and somatoform disorder. Of these ten studies, nine found significant association between disability and somatoform disorder , and while only one study did not find such association. Conclusion: In sum, severe somatization is an entity distinct from depression, which may be as distressing, persistent, refractory, and disabling as the somatic symptoms resulting from several major medical conditions. The results in the current systematic review are consistent with a worldwide growing body of literature that demonstrates that the burden of disability from psychiatric disorders rivals, or exceeds, that associated with medical problems.